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pd166793  (Tocris)
93
Tocris pd166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Pd166793, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/10__3389_slash_fcell__2024__1511908-273-3-4
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pd166793 - by Bioz Stars, 2026-08
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pd166793  (R&D Systems)
90
R&D Systems pd166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Pd166793, supplied by R&D Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/pm36244410-116-26-27
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pd166793 - by Bioz Stars, 2026-08
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control pd166793  (Tocris)
93
Tocris control pd166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Control Pd166793, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/pmc05896266-139-16-18
Average 93 stars, based on 1 article reviews
control pd166793 - by Bioz Stars, 2026-08
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pd 166793  (Bio-Techne corporation)
90
Bio-Techne corporation pd 166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Pd 166793, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/custom%402520%4029674965
Average 90 stars, based on 1 article reviews
pd 166793 - by Bioz Stars, 2026-08
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broad spectrum mmp inhibitor pd166793  (Tocris)
90
Tocris broad spectrum mmp inhibitor pd166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Broad Spectrum Mmp Inhibitor Pd166793, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/pm23830916-79-13-17
Average 90 stars, based on 1 article reviews
broad spectrum mmp inhibitor pd166793 - by Bioz Stars, 2026-08
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bromo biphenyl 4 sulfonyl 3 methyl butyric acid 15 pd 166793  (Tocris)
93
Tocris bromo biphenyl 4 sulfonyl 3 methyl butyric acid 15 pd 166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Bromo Biphenyl 4 Sulfonyl 3 Methyl Butyric Acid 15 Pd 166793, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/us08530453-251-0-10
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bromo biphenyl 4 sulfonyl 3 methyl butyric acid 15 pd 166793 - by Bioz Stars, 2026-08
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mmp inhibitor pd166793  (Tocris)
90
Tocris mmp inhibitor pd166793
FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor <t>PD166793.</t> (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.
Mmp Inhibitor Pd166793, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-166793/PD+166793/pmc03092361-137-25-27
Average 90 stars, based on 1 article reviews
mmp inhibitor pd166793 - by Bioz Stars, 2026-08
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Image Search Results


FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor PD166793. (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.

Journal: Frontiers in Cell and Developmental Biology

Article Title: BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework

doi: 10.3389/fcell.2024.1511908

Figure Lengend Snippet: FIGURE 5 BMP9-induced collagen remodelling is repressed by the MMP inhibitor PD166793. (A) Histogram describing the total loss over 21 days of sGAG to the medium from explants (n = 6, ANOVA, post hoc Tukey). Mean ± SD. (B) Total sGAG loss to the medium over 21 days in control and BMP9 (100 ng mL-1)-cultured explants with or without 10 or 100 μM PD166793 (n = 6). Mean ± SD. (C) Toluidine blue staining, picrosirius red staining, and polarised light microscopy of control and BMP9-cultured explants cultured for 21 days with or without the stated concentrations of PD166793. Bar = 200 μm. Data representative of explants extracted from three different donors. Note the failure of BMP9-cultured explants to partially and completely undergo collagen remodelling when exposed to PD166793; under PLM, collagen fibrils are aligned parallel to the surface, and toluidine staining indicates minimal proteoglycan loss.

Article Snippet: For inhibitor studies, PD166793 (Tocris, UK), dissolved in dimethyl sulphoxide (DMSO), was added at a final concentration of either 10 μM or 100 μM to explant medium, with control explants receiving the same volume of DMSO.

Techniques: Control, Cell Culture, Staining, Light Microscopy